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Meconium aspiration syndrome (MAS) and associated complications management remains an important clinical challenge which sometimes require the use of extracorporeal oxygenation. It occurs in 0.5-1.0 per 100,000 live births in industrialized countries. 20 % of these infants require intubation and are defined as having severe MAS with an overall mortality rate of 7 %.

Superiority of total liquid ventilation (TLV) in therapeutic lung lavage and gas exchange support has been shown in an ovine model of MAS.  Moreover, we shown the possibility of returning newborn lambs to spontaneous breathing within 24 hours without any degradation during next 36 hours. These important results highlight potential and sureness of using TLV as rescue treatment of pulmonary disease opening the way to further clinical trials on severe MAS and acute respiratory disease.