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Therapeutic hypothermia

Mild therapeutic hypothermia (MTH) consists in cooling the body temperature of a patient to between 32 and 34 °C. The International Liaison Committee on Resuscitation (ILCOR) recommends induction of MTH in all unconscious adult patients with spontaneous circulation after resuscitation of out of hospital shockable cardiac arrest. Since 2010, ILCOR also recommends MTH in at term or near term newborn with moderate to severe hypoxia-ischemia.

The current challenge in the research on hypothermia is to obtain a strategy that can induce MTH faster to increase the clinical benefits cooling. Total liquid ventilation (TLV) can induce a rapid lowering of temperature using the wide exchange surface of the lungs, high blood flow around them and the heat capacity of the PFC . PFC may be used to evacuate the heat of the body using the lungs as a heat exchanger while maintaining normal gas exchange. Our results shown that hypothermia can be reached in less than 15 min on newborn lambs. According to finding at Inserm-EnVA U955 (Créteil, France), such ultra-fast induction of hypothermia is able to maximize the neuro and cardio protective effects after cardiac arrest and/or myocardial infarction. It presents the highest cooling efficiency compared to other conventional surface cooling methods used in intensive care units.